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TGIF Polyclonal Antibody

CAT: 0965-JOT-AP08983-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP08983-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by TGIF1 (TGFB induced factor homeobox 1) is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in TGIF1 are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described.
CAS Number
9007-83-4
Synonyms
TGIF1; TGIF; Homeobox protein TGIF1; 5'-TG-3'-interacting factor 1
Host
Rabbit
Reactivity
Human;Mouse;Rat
Immunogen
Synthesized peptide derived from the C-terminal region of human TGIF.
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
43044
Antibody Type
Primary antibody
Isotype
IgG

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