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TGIF Polyclonal Antibody

CAT: 1027-RA30438-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1027-RA30438-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TGFB induced factor homeobox 1 (TGIF1) Homo sapiens The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provide
Product Name Alternative
TGIF1; TGIF; Homeobox protein TGIF1; 5'-TG-3'-interacting factor 1
Gene ID
7050
Swiss Prot
Q15583
Cross Reactivity
Human; Mouse; Rat
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Molecular Weight
43
Storage Conditions
-20°C/1 year
Protein Weight
43

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