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CD135 Recombinant Protein

CAT: 0384-NCP0262-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0384-NCP0262-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
FMS-related tyrosine kinase 3 (FLT3, also called Flk2), is a member of the type III receptor tyrosine kinase family, which includes c-Kit, PDGFR and M-CSF receptors. FLT3 is expressed on early hematopoietic progenitor cells and supports growth and differentiation within the hematopoietic system. FLT3 is activated after binding with its ligand FL, which results in a cascade of tyrosine autophosphorylation and tyrosine phosphorylation of downstream targets. The p85 subunit of PI3 kinase, SHP2, GRB2 and Shc are associated with FLT3 after FL stimulation. Tyr589/591 is located in the juxtamembrane region of FLT3 and may play an important role in regulation of FLT3 tyrosine kinase activity. Somatic mutations of FLT3 consisting of internal tandem duplications (ITDs) occur in 20% of patients with acute myeloid leukemia.
CAS Number
9000-83-3
Swiss Prot
P36888
Modification Site
NdeI-XhoI
Expression System
Pet-22b (+)
Tag
His-tag
Purity
Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE) .
Solubility
PBS, 4M Urea, PH7.4
Molecular Weight
~57kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Host or Source
E.coli
AA Sequence
AACCAGGATCTGCCGGTTATTAAATGTGTGCTGATTAATCATAAGAACAACGATAGCAGCGTGGGCAAAAGCAGCAGCTATCCGATGGTTAGCGAAAGTCCGGAAGATCTGGGTTGTGCACTGCGTCCGCAGAGTAGTGGCACCGTGTATGAAGCCGCCGCAGTGGAAGTTGATGTGAGTGCAAGTATTACCCTGCAGGTGCTGGTTGATGCCCCGGGCAATATTAGTTGTCTGTGGGTGTTCAAACATAGTAGCCTGAATTGTCAGCCGCACTTCGATCTGCAGAATCGCGGTGTGGTTAGTATGGTTATTCTGAAAATGACCGAAACACAAGCCGGCGAATATCTGCTGTTCATTCAGAGCGAAGCAACCAATTATACCATTCTGTTCACCGTGAGCATTCGTAATACCCTGCTGTATACCCTGCGTCGTCCGTACTTCCGCAAAATGGAAAATCAGGATGCCCTGGTGTGTATTAGCGAAAGCGTTCCGGAACCGATTGTGGAATGGGTGCTGTGCGATAGCCAGGGTGAAAGCTGTAAAGAAGAAAGTCCGGCAGTGGTGAAAAAAGAAGAAAAAGTTCTGCATGAACTGTTCGGCACCGATATTCGCTGCTGCGCACGTAATGAACTGGGTCGTGAATGTACCCGTCTGTTCACCATTGATCTGAATCAGACCCCGCAGACCACCCTGCCGCAGCTGTTCCTGAAAGTTGGCGAACCGCTGTGGATTCGTTGTAAAGCCGTGCATGTGAATCATGGCTTCGGTCTGACCTGGGAACTGGAAAATAAAGCACTGGAAGAAGGTAATTACTTCGAAATGAGTACCTATAGTACCAATCGTACCATGATTCGTATTCTGTTCGCATTCGTTAGCAGTGTTGCACGCAATGATACCGGCTATTATACCTGCAGCAGCAGTAAACATCCGAGCCAGAGCGCCCTGGTTACCATTGTTGAAAAAGGCTTCATTAATGCCACCAATAGTAGCGAAGATTATGAAATTGATCAGTATGAAGAGTTCTGCTTCAGTGTTCGCTTCAAAGCATATCCGCAGATTCGTTGTACCTGGACCTTCAGTCGCAAAAGCTTCCCGTGCGAACAGAAAGGCCTGGATAATGGTTATAGTATTAGCAAATTCTGCAACCATAAGCATCAGCCGGGTGAATATATCTTCCATGCAGAAAATGATGATGCCCAGTTCACCAAAATGTTCACCCTGAATATTCGTCGCAAACCGCAGGTTCTGGCAGAAGCCAGCGCCAGTCAGGCCAGCTGCTTCAGCGATGGTTATCCGCTGCCGAGTTGGACCTGGAAAAAATGCAGCGATAAAAGCCCGAATTGCACCGAAGAAATTACCGAAGGCGTGTGGAATCGCAAAGCCAATCGTAAAGTGTTCGGCCAGTGGGTTAGCAGTAGTACCCTGAATATGAGTGAAGCAATTAAAGGCTTCCTGGTTAAATGTTGCGCATATAATAGCCTGGGCACCAGCTGTGAAACCATTCTGCTGAATAGCCCGGGCCCGTTCCCGTTCATTCAGGATAATATTAGC

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