RecombinantIL-3β, Rat

CAT: 0384-BK0105-01Size: 10 µgDry Ice: NoHazardous: No
CAT#:0384-BK0105-01Size:10 µg
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Description
Interleukin-3 (IL-3) is a pleiotropic cytokine belonging to the interleukin family. IL-3 shares similarities with Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) and IL-5: they all have a four-helix bundle structure, are located on the same chromosomes in both human and mouse, are produced by activated T cells, and share receptors. The IL-3/IL-5/GM-CSF receptor family members are all heterodimeric, composed of a receptor-specific α chain and a common β chain. IL-3 is also called multi-colony stimulating factor since it stimulates the development and colony formation of multiple lineages of hematopoietic cells by activating intracellular pathways such as Ras-Raf-ERK and JAK/STAT. IL-3 inhibits apoptosis and promotes cell survival by targeting the anti-apoptotic bcl-2 gene family. Recombinant rat Interleukin-3 beta (rrIL-3 beta) produced in E.coli is a single non-glycosylated polypeptide chain containing of 144 amino acids. A fully biologically active molecule, rrIL-3 beta has a molecular mass of 16.3 kDa analyzed by non-reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
CAS Number
9000-83-3
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 95% as analyzed by SDS-PAGE and HPLC.
Bioactivity
ED50 < 5 ng/mL, measured by a cell proliferation assay using NFS-60 cells, corresponding to a specific activity of > 2 x 10ˆ5 units/mg.
Reconstitution
Reconstituted in ddH2O at 100 μg/mL.
Molecular Weight
16.3 kDa, observed by non-reducing SDS-PAGE.
Storage Conditions
Lyophilized recombinant rat Interleukin-3 beta (rrIL-3 beta) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rrIL-3 beta remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
Lyophilized after extensive dialysis against PBS.
Host or Source
Escherichia coli.
Recommended Usage
This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. For research use only.
AA Sequence
MISDRGSDA HHLLRTLDCR TIALEILVKL PYPQVSGLNN SDDKANLRNS TLRRVNLDEF LKSQEEFDSQ DTTDIKSKLQ KLKCCIPAAA SDSVLPGVYN KDLDDFKKKL RFYVIHLKDL QPVSVSRPPQ PTSSSDNFRP MTVEC

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