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RecombinantIL-3, Human

CAT: 0013-GTR18990511-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR18990511-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Interleukin-3 (IL-3) is a pleiotropic cytokine belonging to the interleukin family. IL-3 shares similarities with Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) and IL-5: they all have a four-helix bundle structure, are located on the same chromosomes in both human and mouse, are produced by activated T cells, and share receptors. The IL-3/IL-5/GM-CSF receptor family members are all heterodimeric, composed of a receptor-specific α chain and a common β chain. IL-3 is also called multi-colony stimulating factor since it stimulates the development and colony formation of multiple lineages of hematopoietic cells by activating intracellular pathways such as Ras-Raf-ERK and JAK/STAT. IL-3 inhibits apoptosis and promotes cell survival by targeting the anti-apoptotic bcl-2 gene family. Recombinant human Interleukin-3 (rhIL-3) produced in E.coli is a single non-glycosylated polypeptide chain containing of 134 amino acids. A fully biologically active molecule, rhIL-3 has a molecular mass of 15.2 kDa analyzed by non-reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Product Name Alternative
Interleukin-3, IL3
Source
Escherichia coli.
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 95% as analyzed by SDS-PAGE and HPLC.
Bioactivity
ED50 2 x 10ˆ7 units/mg.
Form
Lyophilized after extensive dialysis against PBS.
Molecular Weight
15.2 kDa, observed by non-reducing SDS-PAGE.
Storage Conditions
Lyophilized recombinant human Interleukin-3 (rhIL-3) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhIL-3 remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Notes
For research use only.
Applications Notes
Reconstituted in ddH2O at 100 μg/mL.
Preservative
Lyophilized after extensive dialysis against PBS.
AA Sequence
MAPMTQTTP LKTSWVNCSN MIDEIITHLK QPPLPLLDFN NLNGEDQDIL MENNLRRPNL EAFNRAVKSL QNASAIESIL KNLLPCLPLA TAAPTRHPIH IKDGDWNEFR RKLTFYLKTL ENAQAQQTTL SLAIF

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