RecombinantFGF-12, Human

CAT: 0384-BK0035-01Size: 10 µgDry Ice: NoHazardous: No
CAT#:0384-BK0035-01Size:10 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Fibroblast Growth Factor-12 (FGF-12) is a heparin binding cytokine belonging to the FGF family. FGF-12 along with FGF-11, -13, and -14, form a sublineage within the FGF family: in contrast to the other members, they are all intracellular signaling proteins lacking signal peptides and containing a flanking domain beside the family conserved β-trefoil domain. FGF-12 is expressed in the cartilaginous skeleton and heart, suggesting a role in the development of connective tissue and heart. In vivo, FGF-12 binds to Islet Brain-2 and Voltage-Gated Sodium Channels (VGSC), and plays a critical role in the membrane targeting and function of VGSC. FGF-12 has been implicated in heart diseases such as cardiac arrhythmias.Recombinant human Fibroblast Growth Factor-12 (rhFGF-12) produced in E.coli is a single non-glycosylated polypeptide chain containing 181 amino acids. A fully biologically active molecule, rhFGF-12 has a molecular mass of 20.4 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
CAS Number
9000-83-3
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 95% as analyzed by SDS-PAGE and HPLC.
Bioactivity
ED50 < 20 ng/ml, measured by its binding ability in a functional ELISA with immobilized rhFGF R4/Fc Chimera, corresponding to a specific activity of > 5x10ˆ4 units/mg.
Reconstitution
Reconstituted in ddH2O or PBS at 100 μg/ml.
Molecular Weight
20.4 kDa, observed by reducing SDS-PAGE.
Storage Conditions
Lyophilized recombinant human Fibroblast Growth Factor-12 (rhFGF-12) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhFGF-12 remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
Lyophilized after extensive dialysis against PBS.
Host or Source
Escherichia coli.
Recommended Usage
This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. For research use only.
AA Sequence
MESKEPQLK GIVTRLFSQQ GYFLQMHPDG TIDGTKDENS DYTLFNLIPV GLRVVAIQGV KASLYVAMNG EGYLYSSDVF TPECKFKESV FENYYVIYSS TLYRQQESGR AWFLGLNKEG QIMKGNRVKK TKPSSHFVPK PIEVCMYREP SLHEIGEKQG RSRKSSGTPT MNGGKVVNQD ST

Related Products

CatalogName
BK0047-01RecombinantFGF-8e, Human
BK0199-01RecombinantFGF-16, Human
BK0044-01RecombinantFGF-8, Human
BK0045-01RecombinantFGF-8a, Human
BK0048-01RecombinantFGF-8f, Human
BK0051-01RecombinantFGF-acidic, Human
BK0037-01RecombinantFGF-18, Human
BK0043-01RecombinantFGF-6, Human
BK0042-01RecombinantFGF-4, Human
BK0049-01RecombinantFGF-9, Human

Alternative Products

CatalogName
BK0035RecombinantFGF-12,Human
BK0040RecombinantFGF-21,Human
BK0047RecombinantFGF-8e,Human
BK0037RecombinantFGF-18,Human
BK0043RecombinantFGF-6,Human
BK0199RecombinantFGF-16,Human
BK0049RecombinantFGF-9,Human
BK0045RecombinantFGF-8a,Human
BK0042RecombinantFGF-4,Human
BK0044RecombinantFGF-8,Human

Popular Products