RecombinantFGF-8e, Human

CAT: 0384-BK0047-01Size: 10 µgDry Ice: NoHazardous: No
CAT#:0384-BK0047-01Size:10 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fibroblast Growth Factor 8e (FGF-8e) is a cytokine belonging to the heparin-binding FGF family, which has at least 23 members. FGF-8 has 8 different isoforms, named FGF-8a through FGF-8h. Different FGF-8 isoforms have different receptor affinities, and thus participate in different signaling cascade pathways. FGF-8 has widespread expression during embryonic development, promoting gastrulation, somitogenesis, morphogenesis, and limb formation. FGF-8 also has oncogenic potential. While in normal cells FGF-8 is expressed at very low levels, in breast, prostate and ovarian cancer FGF-8 is highly expressed.FGF-8 promotes tumor angiogenesis by increasing neovascularization, and inducing osteoblastic differentiation. Recombinant Human FGF-8e produced in E.coli is a single non-glycosylated polypeptide chain containing 212 amino acids. A fully biologically active molecule, rhFGF-8e has a molecular mass of 24.3 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
CAS Number
9000-83-3
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 95% as analyzed by SDS-PAGE
Bioactivity
ED50 < 2.5µg/ml in the presence of 1 µg/mL heparin, measured in a cell proliferation assay using 3T3.
Reconstitution
Reconstituted in ddH2O or PBS at 100 μg/ml.
Molecular Weight
24.3 kDa, observed by reducing SDS-PAGE.
Storage Conditions
Lyophilized recombinant Human FGF 8e remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Human FGF 8e should be stable up to 1 week at 4°C or up to 3 months at -20°C.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
Lyophilized after extensive dialysis against PBS.
Host or Source
Escherichia coli.
Recommended Usage
This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. For research use only.
AA Sequence
MQEGPGRGPA LGRELASLFR AGREPQGVSQ QHVREQSLVT DQLSRRLIRT YQLYSRTSGK HVQVLANKRI NAMAEDGDPF AKLIVETDTF GSRVRVRGAE TGLYICMNKK GKLIAKSNGK GKDCVFTEIV LENNYTALQN AKYEGWYMAF TRKGRPRKGS KTRQHQREVH FMKRLPRGHH TTEQSLRFEF LNYPPFTRSL RGSQRTWAPE PR

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