RecombinantAITRL, Mouse

CAT: 0384-BK0005-01Size: 10 µgDry Ice: NoHazardous: No
CAT#:0384-BK0005-01Size:10 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Activation-Inducible TNF-Related Ligand (AITRL), also known as Glucocorticoid-Induced TNF-Related Ligand (GITRL), belongs to the tumor necrosis factor superfamily (TNFSF) . AITRL is a Type II single transmembrane protein and shares low conservation within the extracellular domain with other TNFSF members. AITRL is expressed on macrophages, immature and mature dendritic cells and B cells. Its receptor, Activation-Inducible TNFR family Receptor (AITR), is expressed on T lymphocytes, natural killer (NK) cells, and antigen- presenting cells. After binding by AITRL, AITR can be released. AITR activation increases resistance to tumors and viral infections and is involved in autoimmune and inflammatory processes. In addition, activated AITR increases TCR-induced T cell proliferation and cytokine production and rescues T cells and NK cells from apoptosis. Recombinant mouse Activation-Inducible TNF-Related Ligand (rmAITRL) produced in E.coli is a single non-glycosylated polypeptide chain containing 127 amino acids. A fully biologically active molecule, rmAITRL has a molecular mass of 14.5 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
CAS Number
9000-83-3
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 95% by SDS-PAGE and HPLC analyses.
Bioactivity
ED50 < 5 ng/mL, measured by the amount of Interleukin-8 produced by PMBC, corresponding to a specific activity of > 2.0 x 10ˆ5 units/mg.
Reconstitution
Reconstituted in ddH2O at 100 μg/mL.
Molecular Weight
14.5 kDa, observed by reducing SDS-PAGE.
Storage Conditions
Lyophilized recombinant mouse Activation-Inducible TNF-Related Ligand (rmAITRL) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rmAITRL remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
Lyophilized after extensive dialysis against PBS.
Host or Source
Escherichia coli.
Recommended Usage
This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. For research use only.
AA Sequence
TAI ESCMVKFELS SSKWHMTSPK PHCVNTTSDG KLKILQSGTY LIYGQVIPVD KKYIKDNAPF VVQIYKKNDV LQTLMNDFQI LPIGGVYELH AGDNIYLKFN SKDHIQKTNT YWGIILMPDL PFIS

Related Products

CatalogName
BK0004-01RecombinantAITRL, Human
BK0289-01RecombinantTPO, Mouse
BK0009-01RecombinantBetacellulin, Mouse
BK0148-01RecombinantOSM, Mouse
BK0007-01RecombinantApril, Mouse
BK0122-01RecombinantLIF, Mouse
BK0027-01RecombinantEGF, Mouse
BK0209-01RecombinantGDNF, Mouse
BK0022-01RecombinantDHH, Mouse
BK0162-01RecombinantShh, Mouse

Alternative Products

CatalogName
BK0005RecombinantAITRL,Mouse
BK0004RecombinantAITRL,Human
RC444043Mouse Mouse MIG
117004Mouse IgG1 Mouse
117005Mouse IgG2a Mouse
117006Mouse IgG2b Mouse
MBS224809-01MOUSE ANTI MOUSE CD32B
MBS135005-01Mouse monoclonal to mouse tPA
MBS8538288-01TUG (Mouse) Mouse mAb
AR01002PU-NMouse IgE Mouse Protein

Popular Products