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APOBEC3D/APOBEC3F polyclonal antibody

CAT: 0384-BS61718-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS61718-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DNA dC->dU-editing enzyme APOBEC-3D/3F, DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
DNA dC->dU-editing enzyme APOBEC-3D; A3D; APOBEC3D; DNA dC->dU-editing enzyme APOBEC-3F; Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F; A3F; APOBEC3F
Swiss Prot
Q96AK3/Q8IUX4
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 220-270 of Human APOBEC3D.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 45 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
APOBEC3D/APOBEC3F polyclonal antibody detects endogenous levels of APOBEC3D/APOBEC3F protein.
Applications Notes
Western blot (WB) analysis of APOBEC3D/APOBEC3F polyclonal antibody at 1:500 dilution Lane1:H1792 whole cell lysate (40ug) Lane2:SK-OVCAR3 whole cell lysate (40ug) Lane3:H9C2 whole cell lysate (40ug) Lane4:MEF whole cell lysate (40ug)
Host or Source
Rabbit

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