Anti-APOBEC3D/APOBEC3F Antibody

• Description:

  Boster Bio Anti-APOBEC3D/APOBEC3F Antibody catalog # A08491. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  DNA dC->dU-editing enzyme APOBEC-3D; A3D;3.5.4.38; APOBEC3D;

• Gene Name:

  APOBEC3D

• UniProt:

  Q96AK3/Q8IUX4

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic peptide, corresponding to amino acids 220-270 of Human APOBEC3D.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung.

• Applications:

  WB

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Dilution:

  WB: 1:500-1:1000

• Form:

  Liquid

• Function:

  DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons.

• Molecular Weight:

  46598 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  DNA dC->dU-editing enzyme APOBEC-3D

• Subcellular Location:

  Cytoplasm. Cytoplasm, P-body.

• Protein Name:

  DNA dC->dU-editing enzyme APOBEC-3D