DCLK3 polyclonal antibody

CAT: 0384-BS61555-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS61555-01Size:50 µL
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Background
DCLK3 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK3 mRNA, like that of the homologous DCLK1 and DCLK3, is highly expressed in adult brain, but only DCLK3 transcripts are present in liver and kidney, suggesting that DCLK3 may play other roles than in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a protein that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization.Synonyms: DCAMKL3, DCDC3C, DCK3, DCLK3, KIAA1765, Serine/threonine-protein kinase DCLK3.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Serine/threonine-protein kinase DCLK3; Doublecortin domain-containing protein 3C; Doublecortin-like and CAM kinase-like 3; Doublecortin-like kinase 3
Swiss Prot
Q9C098
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 272-316 of Human DCLK3
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Modification
Unmodification
Molecular Weight
~ 80 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
DCLK3 polyclonal antibody detects endogenous levels of DCLK3 protein.
Applications Notes
Western blot (WB) analysis of DCLK3 polyclonal antibody at 1:500 dilution Lane1:The Liver lysate of Rat (40ug) Lane2:The Kidney lysate of Rat (40ug) Lane3:The Lung lysate of Mouse (40ug) Lane4:HCT116 whole cell lysate (20ug) Lane5:A549 whole cell lysate (40ug)
Host or Source
Rabbit

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