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LYL1 polyclonal antibody

CAT: 0384-BS61016-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS61016-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Lyl-1, TAL1 and TAL2 are part of a family of basic helix-loop-helix (bHLH) proteins implicated in T cell acute leukemia. TAL1, also designated SCL, is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. TAL2 is a protein involved in T cell acute lymphoblastic leukemia through a chromosomal translocation involving TAL2 and T cell receptor β chain genes. TAL2 includes a helix-loop-helix protein dimerization and DNA-binding domain that is homologous to TAL1 and Lyl-1 proto-oncogenes. Lyl-1 (lymphoblastic leukemia-derived sequence 1) is a nuclear protein. Endogenous Lyl-1 exists in complex with E2α proteins. Lyl-1 and E2α protein can form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells. Lyl-1 is involved in a chromosomal aberration which causes a form of T cell acute lymphoblastic leukemia (T-ALL) .
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Protein lyl-1; Class A basic helix-loop-helix protein 18; bHLHa18; Lymphoblastic leukemia-derived sequence 1; LYL1; BHLHA18
Swiss Prot
P12980
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues in Human LYL1.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 30 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
LYL1 polyclonal antibody detects endogenous levels LYL1 protein.
Applications Notes
Western blot (WB) analysis of LYL1 polyclonal antibody at 1:500 Line1:HEK293T whole cell lysate Line2:H9C2 whole cell lysate Line3:Raw264.7 whole cell lysate
Host or Source
Rabbit

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