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PPARγ (phospho-S112) polyclonal antibody

CAT: 0384-BS4444-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS4444-01Size:50 µL
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Background
PPAR gamma is implicated in numerous diseases including obesity, diabetes, atherosclerosis and cancer. PPAR gamma activators include prostanoids, fatty acids, thiazolidinediones and N- (2-benzoylphenyl) tyrosine analogues. A key component in adipocyte differentiation and fat-specific gene expression, PPAR gamma may modulate macrophage functions such as proinflammatory activities, and stimulate oxidized low-density lipoprotein (x-LDL) uptake. A Pro12Ala polymorphism of the PPAR gamma2 gene has been reported to reduce transactivation activity in vitro. This substitution may affect the immune response to ox-LDL and be associated with type 2 diabetes. In addition, the Pro12Ala variant of the PPAR gamma2 gene maybe correlated with abdominal obesity in type 2 diabetes.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Peroxisome proliferator-activated receptor gamma; Short name=PPAR-gamma; Nuclear receptor subfamily 1 group C member 3; PPARG; NR1C3; PPAR γ; PPARγ
Swiss Prot
P37231
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic phosphopeptide derived from human PPARγ around the phosphorylation site of Serine 112.
Conjugation
Unconjugated
Related Pathways
Nuclear Receptor Signaling, MTOR signaling
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Phosphorylation
Molecular Weight
~ 54 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
P-PPARγ (S112) polyclonal antibody detects endogenous levels of PPARγ protein only when phosphorylated at Ser112.
Applications Notes
Western blot (WB) analysis of p-PPAR-γ (S112) polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate treated with colchicine Lane2:Raw264.7 cell lysate treated with colchicine Lane3:PC12 cell lysate treated with colchicine
Host or Source
Rabbit

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