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IL21R polyclonal antibody

CAT: 0384-BS62606-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS62606-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21) . It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.
Product Name Alternative
Interleukin-21 receptor; IL-21 receptor; IL-21R; Novel interleukin receptor; CD360; IL21R; NILR; UNQ3121; PRO10273
Swiss Prot
Q9HBE5
Reactivity
Human, Mouse
Immunogen
Synthetic peptide, corresponding to Human IL21R.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 100 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IL21R polyclonal antibody detects endogenous levels of IL21R protein.
Applications Notes
Western blot (WB) analysis of IL21R polyclonal antibody at 1:500 dilution LaneA:HEK293T whole cell lysate (40ug) LaneB:A549 whole cell lysate (40ug)
Host or Source
Rabbit

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