GLRB Polyclonal Antibody

• Background :

  GLRB (Glycine receptor beta) is a neurotransmitter-gated ion channel concentrated within the spinal cord and brainstem. Expression is also observed in several upper brain regions including the cortex, cerebellum, hippocampus and amygdala. Binding of glycine to GLRB increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing), controlling spinal reflexes and locomotor behavior.

• Structure Composition :

  0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Product Name Alternative :

  Glycine receptor 58 kDa subunit; Glycine receptor beta; Glycine receptor subunit beta; Glycine receptor, beta subunit; GLRB_HUMAN.

• Swiss Prot :

  P48167

• Reactivity :

  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep

• Conjugation :

  Unconjugated

• Applications :

  IHC-P

• Dilution :

  IHC-P=1:100-500

• Purity :

  Affinity purified by Protein A

• Modification :

  Unmodification

• Molecular Weight :

  ~54kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -29°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  GLRB Polyclonal Antibody detects endogenous levels of GLRB protein.

• Applications Notes :

  Paraformaldehyde-fixed, paraffin embedded (mouse cerebellum) ; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GLRB) Polyclonal Antibody, Unconjugated at 1:200 overnight at 4°C

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4