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LPHN1 Polyclonal Antibody

CAT: 0384-BS65810-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS65810-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR) . Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
CAS Number
9007-83-4
Structure Composition
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Product Name Alternative
Calcium independent alpha latrotoxin receptor 1; Calcium-independent alpha-latrotoxin receptor 1; CIRL-1; CIRL1; CL1; CLIBA; G protein-coupled receptor for alpha-Latrotoxin; KIAA0821; Latrophilin 1; Latrophilin-1; Latrophilin1; LEC2; Lectomedin 2; Lectomedin-2; LPHN 1; LPHN1; LPHN1_HUMAN.
Swiss Prot
O94910
Reactivity
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit
Conjugation
Unconjugated
Applications
IHC-P
Dilution
IHC-P=1:100-500
Purity
Affinity purified by Protein A
Modification
Unmodification
Molecular Weight
~160 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -17°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
LPHN1 Polyclonal Antibody detects endogenous levels of LPHN1 protein.
Applications Notes
Paraformaldehyde-fixed, paraffin embedded (rat kidney) ; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (LPHN1) Polyclonal Antibody, Unconjugated at 1:200 overnight at 4°C
Host or Source
Rabbit

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