BBS1 Polyclonal Antibody

• Background :

  The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8 (GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane.

• Structure Composition :

  0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Product Name Alternative :

  AI451249; Bardet-Biedl syndrome 1; Bardet-Biedl syndrome 1 homolog; Bardet-Biedl syndrome 1 protein; BBS1; BBS1_HUMAN; BBS2-like protein 2; D19Ertd609e.

• Swiss Prot :

  Q8NFJ9

• Reactivity :

  Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep

• Immunogen :

  KLH conjugated synthetic peptide derived from human BBS5

• Conjugation :

  Unconjugated

• Applications :

  WB, IHC-P

• Dilution :

  WB=1:500-2000 IHC-P=1:100-500

• Purity :

  Affinity purified by Protein A

• Modification :

  Unmodification

• Molecular Weight :

  65 kD

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  BBS1 Polyclonal Antibody detects endogenous levels of BBS1 protein.

• Applications Notes :

  Sample: HepG2 (Human) Cell Lysate at 30 ug U2os (Human) Cell Lysate at 30 ug Primary: Anti- BBS1 at 1/1000 dilution

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4