CD49e polyclonal antibody

• Background:

  Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival. The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities. Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling) . Integrin α5/β1 is involved in multiple biological processes including embryonic development, angiogenesis and tumor metastasis. By interaction with its fibronectin ligand, α5/β1 transduces signals that regulate cell adhesion, migration, matrix assembly and cytoskeletal organization.

• Structure Composition:

  Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

• Product Name Alternative:

  FNRA; Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD49e

• Swiss Prot:

  P08648

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein corresponding to human CD49e. The exact sequence is proprietary.

• Conjugation:

  Unconjugated

• Related Pathways:

  Regulation of Actin Dynamics, G Protein-coupled Receptors Signaling to MAPK Erk, MAPK Erk in Growth and Differentiation Pathway, PI3K AKT signaling

• Applications:

  WB, IF/ICC

• Dilution:

  WB (1/500 - 1/1000), IF/ICC (1/50 - 1/200)

• Purity:

  The antibody was purified by immunogen affinity chromatography.

• Modification:

  Unmodification

• Molecular Weight:

  ~ 130 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  Recognizes endogenous levels of CD49e protein.

• Applications Notes:

  Western blot analysis of CD49e expression in NIH3T3 (A), HT1080 (B), rat heart (C) whole cell lysates.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4