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CD49f monoclonal antibody

CAT: 0384-MB66935-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-MB66935-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival. The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities . Integrins not only transmit signals to cells in response to the extracellular environment , but also sense intracellular cues to alter their interaction with the extracellular environment . Integrin α6 is a 120 kDa protein with two splice variants, integrin α6, 6A and 6B , which function as receptors for laminins on the basal membrane to mediate cellular adhesion events . α6 integrins have been shown to play an important role in hematopoietic stem and progenitor cell homing to the bone marrow.
CAS Number
9007-83-4
Structure Composition
Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
Integrin alpha-6; CD49 antigen-like family member F; VLA-6; CD49f
Swiss Prot
P23229
Reactivity
Human
Immunogen
Recombinant fusion protein of human CD49f. The exact sequence is proprietary.
Conjugation
Unconjugated
Related Pathways
Regulation of Actin Dynamics, G Protein-coupled Receptors Signaling to MAPK Erk, PI3K AKT signaling
Applications
WB, IHC, IF/ICC, FC
Dilution
WB (1/1000 - 1/5000), IHC (1/50 - 1/200), IF/ICC (1/10 - 1/50), FC (1/10 - 1/50)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 130 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of CD49f protein.
Applications Notes
Western blot analysis of CD49f expression in HepG2 (A) whole cell lysates.
Host or Source
Mouse

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