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LATS2 polyclonal antibody

CAT: 0384-BS67464-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS67464-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Large tumor suppressor kinase 2 (LATS2) is an AGC kinase of the NDR family of kinases. It is a LATS family tumor suppressor that plays a critical role in centrosome duplication, maintenance of mitotic fidelity, and genomic stability. LATS2 inhibits cell growth at the G1/S transition by down-regulating cyclin E/CDK2 kinase activity. It also plays an important role in regulation of the Hippo pathway, which is important in controlling organ size and tumor progression by regulating cellular proliferation and promoting apoptosis.
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
KPM; Serine/threonine-protein kinase LATS2; Kinase phosphorylated during mitosis protein; Large tumor suppressor homolog 2; Serine/threonine-protein kinase kpm; Warts-like kinase
Swiss Prot
Q9NRM7
Reactivity
Human
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human LATS2. The exact sequence is proprietary.
Conjugation
Unconjugated
Related Pathways
Hippo Signaling.
Applications
WB, IHC, IF/ICC
Dilution
WB (1/500 - 1/1000), IHC (1/50 - 1/200), IF/ICC (1/50 - 1/200)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 150 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of LATS2 protein.
Applications Notes
Western blot analysis of LATS2 expression in A549 (A), SGC7901 (B) whole cell lysates.
Host or Source
Rabbit

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