Products for Research Use Only
RegisterLogin

LATS1 polyclonal antibody

CAT: 0384-BS80186-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0384-BS80186-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
CAS Number
9007-83-4
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
LATS1; WARTS; wts
Swiss Prot
O95835
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human LATS1 (NP_004681.1) .
Conjugation
Unconjugated
Applications
WB, IHC
Dilution
WB,1:500 - 1:2000|IHC,1:50 - 1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
150KDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Unmodification
Host or Source
Rabbit

Related Products

CatalogName
BS48812-01LATS1/WARTS Recombinant Rabbit mAb
BS67464-01LATS2 polyclonal antibody
BS79998-01LATS2 polyclonal antibody
BS70514-01LAT1/SLC7A5 polyclonal antibody
BZ16794-01Polyclonal antibodyPN1 polyclonal antibody
BS75206-01AaaaaASPH polyclonal antibody
BS5662-01CHST1 polyclonal antibody
BS71123-01COPS7A polyclonal antibody
BS65479-01GDN Polyclonal Antibody
BS8691-01TUSC2 polyclonal antibody

Alternative Products

CatalogName
GTR18043546-01LATS1 polyclonal antibody
GTR18034811-01LATS1 Rabbit Polyclonal Antibody
NBP1-58271Rabbit Polyclonal LATS1 Antibody
MBS9433524-01LATS1/LATS2 Polyclonal Antibody
ABP59096-01LATS1/2 Polyclonal Antibody
TMAB-01050-01Anti-LATS1 Polyclonal Antibody

Popular Products