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PDE6G polyclonal antibody

CAT: 0384-BS67455-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS67455-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Phosphodiesterases (PDEs, also designated cyclic nucleotide phosphodiesterases) are important for the downregulation of the intracellular evel of the second messenger cyclic adenosine monophosphate (cAMP), as they are responsible for hydrolyzing cAMP to 5'AMP. PDE6G, also designated phosphodiesterase 6G cGMP-specific rod g, is an oligomer composed of two catalytic chains (a and b), an inhibitory chain (g) and an d chain. PDEG6G functions in the processes of transmission and amplification of the visual signal. A mutation in the rod PDE-g gene desensitizes and delays murine rod photoreceptors. PDE6H, also designated phosphodiesterase 6H cGMP-specific cone g, is a tetramer composed of two catalytic chains (a and b) and two inhibitory chains (g) . It functions similarly to PDE6H in vision processes. Defects of the PDE6H gene cause retinal cone dystrophy 3 (rcd3), also designated cone dystrophy with night blindness and supernormal rod responses.
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
PDEG; Retinal rod rhodopsin-sensitive cGMP 3'5'-cyclic phosphodiesterase subunit gamma; GMP-PDE gamma
Swiss Prot
P18545
Reactivity
Human, Mouse, Rat, Bovine, Dog
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PDE6G. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 19 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of PDE6G protein.
Applications Notes
Western blot analysis of PDE6G expression in mouse eyes (A), rat eyes (B) whole cell lysates.
Host or Source
Rabbit

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