Perforin polyclonal antibody

• Background :

  The protein encoded by this gene has structural and functional similarities to complement component 9 (C9) . Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.

• Structure Composition :

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

• Product Name Alternative :

  Perforin-1; P1; Cytolysin; Lymphocyte pore-forming protein; PFP

• Swiss Prot :

  P14222

• Reactivity :

  Human

• Immunogen :

  The antiserum was produced against synthesized peptide derived from the C-terminal region of human PRF1. AA range:451-500

• Conjugation :

  Unconjugated

• Applications :

  WB, IHC-P, ELISA

• Dilution :

  WB: 1/500-1/1000 IHC: 1/50-1/100 ELISA: 1/10000

• Purity :

  Affinity Purified

• Modification :

  Unmodified

• Molecular Weight :

  Calculated MW: 61 kDa; Observed MW: 61 kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  IgG

• Applications Notes :

  Western blot analysis of Perforin in Hela lysates using Perforin antibody.

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4