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Perforin 1 Polyclonal Antibody

CAT: 0965-JOT-AP07063-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP07063-01Size:20 µL
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Background
The protein encoded by PRF1 (perforin 1) has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in PRF1 cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.
CAS Number
9007-83-4
Synonyms
Perforin-1 (P1) (Cytolysin) (Lymphocyte pore-forming protein) (PFP)
Host
Rabbit
Reactivity
Human
Immunogen
The antiserum was produced against synthesized peptide derived from the C-terminal region of human PRF1. AA range:451-500
Clonality
Polyclonal
Applications
WB, IHC, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
61377
Antibody Type
Primary antibody
Isotype
IgG

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