CD63 polyclonal antibody

• Background :

  The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms.

• Structure Composition :

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative :

  CD63; LAMP-3; ME491; MLA1; OMA81H; TSPAN30; CD63 antigen; CD63

• Swiss Prot :

  P08962

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein of human CD63 (NP_001771.1) .

• Conjugation :

  Unconjugated

• Applications :

  WB, IHC, IF/ICC

• Dilution :

  WB,1:500 - 1:2000|IHC,1:50 - 1:200|IF/ICC,1:50 - 1:200

• Purity :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification :

  Unmodified

• Molecular Weight :

  ~ 30-65 kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  CD63 polyclonal antibody detects endogenous levels of CD63 protein.

• Applications Notes :

  Western blot analysis of CD63 expression in HL-60 (A), RAW264.7 (B), rat brain (C) whole cell lysates.

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4