CD63 monoclonal antibody

• Background:

  CD63 belongs to the tetraspanin family, which is characterized by four transmembrane domains, one short extracellular domain (ECL1), and one long extracellular domain (ECL2) . Tetraspanins interact with a variety of cell surface proteins and intracellular signaling molecules in specialized tetraspanin-enriched microdomains (TEMs) where they mediate a range of processes, including adhesion, motility, membrane organization, and signal transduction. CD63, like other tetraspanins, is enriched in exosomes. It is also a component of Weibel-Palade bodies found in endothelial cells. Research studies demonstrate several functions of CD63 in different cell types, including roles in mast cell degranulation, VEGF signaling in endothelial cells, recruitment of leukocytes to endothelial cells, and endosomal sorting during melanogenesis.

• Structure Composition:

  Mouse IgG1. Liquid in PBS, pH 7.3, and 0.02% sodium azide.

• Product Name Alternative:

  MLA1; TSPAN30; CD63 antigen; Granulophysin; Lysosomal-associated membrane protein 3; LAMP-3; Melanoma-associated antigen ME491; OMA81H; Ocular melanoma-associated antigen; Tetraspanin-30; Tspan-30; CD antigen CD63

• Swiss Prot:

  P08962

• Reactivity:

  Human

• Immunogen:

  Native purified human CD63.

• Conjugation:

  Unconjugated

• Applications:

  IF, FC

• Dilution:

  IF (1/50 - 1/200)

• Purity:

  The monoclonal antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  ~ 25 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  Recognizes human CD63

• Applications Notes:

  Flow cytometric analysis of human platelets using Anti-CD63 Antibody, followed by anti-mouse IgG PE.

• Host or Source:

  Mouse

• CAS Number:

  9007-83-4