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Cleaved-KLK11 (I54) polyclonal antibody

CAT: 0384-BS7059-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS7059-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Human pancreatic/renal KLK encodes for the KLK1 enzyme, which is involved in post-translational processing of polypeptide precursors. The function of the other members of KLK gene family is currently unknown, but evidence suggests that many KLKs are implicated in carcinogenesis. The human KLK gene family consists of 15 serine proteases. The human KLK genes are clustered on chromosome 19q13. Unlike other kalllikreins, the KLK4-15 encoded proteases are less related and do not contain a conventional KLK loop. Clusters of genes exhibit high prostatic (KLK2-4, KLK15) or pancreatic (KLK6-13) expression . KLK2 is also known as glandular kallikrein 2, tissue kallikrein or HGK-1, and KLK3 is known as prostate-specific antigen (PSA) . Both KLK2 and KLK3 have important applications in prostate cancer and breast cancer diagnostics. KLK4, KLK5, KLK9, KLK13, KLK12 and KLK14 have been previously known as KLK-L1, KLK-L2, KLK-L3, KLK-L4, KLK-L5 and KLK-L6, respectively.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Kallikrein-11; hK11; Hippostasin; Serine protease 20; Trypsin-like protease; Kallikrein-11 inactive chain 1; Kallikrein-11 inactive chain 2; KLK11; PRSS20; TLSP; UNQ649/PRO1279; Kallikrein 11; Kallikrein11
Swiss Prot
Q9UBX7
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 23-71 of Human Cleaved-KLK11.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Cleaved
Molecular Weight
~ 25, 15 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Cleaved-KLK11 (I54) polyclonal antibody detects endogenous levels of Cleaved-KLK11 (25 kDa) protein.
Applications Notes
Western blot (WB) analysis of Cleaved-KLK11 (I54) pAb at 1:500 dilution Lane1:C6 whole cell lysate (40ug) Lane2:BV2 whole cell lysate (40ug) Lane3:U-87MG whole cell lysate (40ug) Lane4:A2780 whole cell lysate (40ug)
Host or Source
Rabbit

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