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DBPR108

CAT: 0804-HY-12528-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-12528-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DBPR108 is a potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15 nM; no inhibition on DDP8 and DPP9. IC50 value: 15 nM [1] Target: DPP4 inhibitor DBPR108 is an IC50=15 nM DPP IV inhibitor displays a more than 3000-fold selectivity over DPP8 DPP9, FAP and DPP-II. TThe in vivo effects of DBPR108, including inhibition of plasma DPP-IV activity and suppression of blood glucose elevation, were also demonstrated. DBPR108 is a potent, selective, long-acting and safe DPP-IV inhibitor as a potential treatment of type 2 diabetes mellitus.
CAS Number
1186426-66-3
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Dipeptidyl Peptidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/DBPR108.html
Purity
99.93
Solubility
DMSO : ≥ 25 mg/mL
Smiles
N#C[C@H]1N(C(CNC(C)(C)CC(N2CCCC2)=O)=O)C[C@@H](F)C1
Molecular Formula
C16H25FN4O2
Molecular Weight
324.39
Precautions
H315, H319, H335
References & Citations
[1]Yeh TK, et al. (2S,4S) -1-[2- (1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino) acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV. Bioorg Med Chem Lett. 2010 Jun 15;20 (12) :3596-600.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
DPP-4

Chemical Information

(2S,4S)-4-fluoro-1-(2-((2-methyl-4-oxo-4-pyrrolidin-1-ylbutan-2-yl)amino)acetyl)pyrrolidine-2-carbonitrile

Prusogliptin is a small molecule drug. The usage of the INN stem '-gliptin' in the name indicates that Prusogliptin is a dipeptidyl aminopeptidase-IV inhibitor. Prusogliptin is under investigation in clinical trial NCT07026968 (A Study of Prusogliptin Tablets Combined With Dapagliflozin Tablets and Metformin Hydrochloride Extended Release Tablets in Type 2 Diabetes). Prusogliptin has a monoisotopic molecular weight of 324.2 Da.

CAS Number1186426-66-3
PubChem CID44201003
IUPAC Name(2S,4S)-4-fluoro-1-[2-[(2-methyl-4-oxo-4-pyrrolidin-1-ylbutan-2-yl)amino]acetyl]pyrrolidine-2-carbonitrile
Molecular FormulaC16H25FN4O2
Molecular Weight324.39
XLogP0.2
Topological Polar Surface Area76.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count23
Formal Charge0
Complexity507
SMILES
CC(C)(CC(=O)N1CCCC1)NCC(=O)N2C[C@H](C[C@H]2C#N)F
InChI
InChI=1S/C16H25FN4O2/c1-16(2,8-14(22)20-5-3-4-6-20)19-10-15(23)21-11-12(17)7-13(21)9-18/h12-13,19H,3-8,10-11H2,1-2H3/t12-,13-/m0/s1
InChIKey
VQKSCYBKUIDZEI-STQMWFEESA-N
Chemical Structure
2D Structure
2D structure of (2S,4S)-4-fluoro-1-(2-((2-methyl-4-oxo-4-pyrrolidin-1-ylbutan-2-yl)amino)acetyl)pyrrolidine-2-carbonitrile
CAS: 1186426-66-3
CID: 44201003
Formula: C16H25FN4O2
MW: 324.39
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight324.39
XLogP30.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass324.19615422
Monoisotopic Mass324.19615422
Topological Polar Surface Area76.4 Ų
Heavy Atom Count23
Formal Charge0
Complexity507
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
BA7308-5DBPR108
A21833-50DBPR108 50mg
A21833-25DBPR108 25mg
A21833-10DBPR108 10mg
A21833-5DBPR108 5mg
A21833-1DBPR108 1mg
A21833-200DBPR108 200mg
A21833-100DBPR108 100mg
A21833-10mM-DDBPR108 10mM * 1mL in DMSO

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