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DBPR108

CAT: 0931-T15079-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T15079-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1186426-66-3
Target
Proteasome, DPP-4
Related Pathways
Proteases/Proteasome, Ubiquitination
Purity
0.9968
Bioactivity
DBPR108 is an orally bioavailable dipeptide-derived DPP4 inhibitor (IC50: 15 nM) and it has no inhibition on DDP8 and DPP9.
Smiles
CC(C)(CC(=O)N1CCCC1)NCC(=O)N1C[C@@H](F)C[C@H]1C#N
Molecular Formula
C16H25FN4O2
Molecular Weight
324.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

(2S,4S)-4-fluoro-1-(2-((2-methyl-4-oxo-4-pyrrolidin-1-ylbutan-2-yl)amino)acetyl)pyrrolidine-2-carbonitrile

Prusogliptin is a small molecule drug. The usage of the INN stem '-gliptin' in the name indicates that Prusogliptin is a dipeptidyl aminopeptidase-IV inhibitor. Prusogliptin is under investigation in clinical trial NCT07026968 (A Study of Prusogliptin Tablets Combined With Dapagliflozin Tablets and Metformin Hydrochloride Extended Release Tablets in Type 2 Diabetes). Prusogliptin has a monoisotopic molecular weight of 324.2 Da.

CAS Number1186426-66-3
PubChem CID44201003
IUPAC Name(2S,4S)-4-fluoro-1-[2-[(2-methyl-4-oxo-4-pyrrolidin-1-ylbutan-2-yl)amino]acetyl]pyrrolidine-2-carbonitrile
Molecular FormulaC16H25FN4O2
Molecular Weight324.39
XLogP0.2
Topological Polar Surface Area76.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count23
Formal Charge0
Complexity507
SMILES
CC(C)(CC(=O)N1CCCC1)NCC(=O)N2C[C@H](C[C@H]2C#N)F
InChI
InChI=1S/C16H25FN4O2/c1-16(2,8-14(22)20-5-3-4-6-20)19-10-15(23)21-11-12(17)7-13(21)9-18/h12-13,19H,3-8,10-11H2,1-2H3/t12-,13-/m0/s1
InChIKey
VQKSCYBKUIDZEI-STQMWFEESA-N
Chemical Structure
2D Structure
2D structure of (2S,4S)-4-fluoro-1-(2-((2-methyl-4-oxo-4-pyrrolidin-1-ylbutan-2-yl)amino)acetyl)pyrrolidine-2-carbonitrile
CAS: 1186426-66-3
CID: 44201003
Formula: C16H25FN4O2
MW: 324.39
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight324.39
XLogP30.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass324.19615422
Monoisotopic Mass324.19615422
Topological Polar Surface Area76.4 Ų
Heavy Atom Count23
Formal Charge0
Complexity507
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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BA7308-5DBPR108
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A21833-10DBPR108 10mg
A21833-5DBPR108 5mg
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A21833-100DBPR108 100mg
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