DBPR116

CAT: 0804-HY-159924Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-159924Size:1 Each

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Description

DBPR116 is a prodrug of BPRMU191 with blood-brain barrier penetration capability. DBPR116 significantly improves the delivery of centrally targeted drugs. In combination with the antagonist Naltrexone (HY-76711), DBPR116 demonstrated superior safety and analgesic efficacy compared to morphine in various in vivo pharmacological studies, including thermal pain models, cancer pain models, constipation, sedation, psychological dependence, heart rate, and respiratory frequency. As a prodrug strategy for peripheral administration, DBPR116 effectively alleviates pain while reducing adverse effects, showing potential as a safer opioid analgesic[1].

CAS Number

2131200-75-2

UNSPSC

12352005

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dbpr116.html

Smiles

O=C(C1=CC=C(N2C(CSC2C3=CC=C(C=C3)F)=O)C(C)=C1)OCC

Molecular Formula

C19H18FNO3S

Molecular Weight

359.41

References & Citations

[1]Lin SY, et al. DBPR116, a Prodrug of BPRMU191, in Combination with Naltrexone as a Safer Opioid Analgesic Than Morphine via Peripheral Administration. J Med Chem. 2024 Nov 14;67 (21) :19777-19790.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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