DBPR110

CAT: 0804-HY-114216Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-114216Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

DBPR110 is a nonstructural protein 5A (NS5A) inhibitor with inhibitory activity against hepatitis C virus (HCV) . DBPR110 exhibited a 50% effective concentration (EC50) of 3.9 ± 0.9 pM and a selectivity index value of over 12,800,000 by reducing HCV1b replicon reporter expression. DBPR110 also effectively reduced the activity of HCV2a replicon with an EC50 of 228.8 pM and a selectivity index value of over 173,130. DBPR110 showed synergy with interferon alpha (IFN-α), NS3 protease inhibitors, and NS5B polymerase inhibitors. The results of DBPR110 suggest that it may be an effective small molecule inhibitor against HCV NS5A[1].

CAS Number

1310694-75-7

UNSPSC

12352005

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dbpr110.html

Smiles

O=C(C1CC1)N[C@H](C2=CC=CC=C2)C(N3[C@H](C4=NC=C(C5=CC=C(C6=CC=C(C7=CN=C([C@H]8N(CCC8)C([C@@H](C9=CC=CC=C9)NC(C%10CC%10)=O)=O)S7)C=C6)C=C5)S4)CCC3)=O

Molecular Formula

C50H48N6O4S2

Molecular Weight

861.08

References & Citations

[1]Resistance studies of a dithiazol analogue, DBPR110, as a potential hepatitis C virus NS5A inhibitor in replicon systems

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

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HY-159924	DBPR116
HY-12528-01	DBPR108

DBPR110

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