FHR5 rabbit pAb

CAT: 0855-ES16472-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0855-ES16472-01Size:50 µL

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Background

This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS) . [provided by RefSeq, Jan 2010]

Description

This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney Disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). [provided by RefSeq, Jan 2010],

Product Name Alternative

Complement factor H-related protein 5 (FHR-5)

UniProt

Q9BXR6

Swiss Prot

Q9BXR6

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from human FHR5 AA range: 353-403

Target

FHR5

Clonality

Polyclonal

Source

Rabbit

Applications

Concentration

1 mg/ml

Dilution

WB 1:500-2000

Buffer

-20°C/1 year

Molecular Weight

60kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

60kD

Fragment

IgG

Subcellular Location

Secreted.

Other Product Names

Complement factor H-related protein 5 (FHR-5)

Gene ID (Human)

81494

UniProtKB · Q9BXR6

Complement factor H-related protein 5

FHR5_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9BXR6
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CFHR5
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: FHR-5
EC number: —
Processing: Precursor
Secondary accessions: Q2NKK2

Protein keywords

Technical term

Direct protein sequencingProteomics identificationReference proteome

Disease

Disease variantHemolytic uremic syndrome

PTM

Disulfide bondGlycoprotein

Domain

RepeatSignalSushi

Cellular component

Secreted

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