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FHR1 rabbit pAb

CAT: 0855-ES11060-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES11060-01Size:50 µL
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Background
This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009]
Description
This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009],
UniProt
Q03591
Swiss Prot
Q03591
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Target
FHR1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
36kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
36kD
Fragment
IgG
Subcellular Location
Secreted.
Gene ID (Human)
3078

UniProtKB · Q03591

Complement factor H-related protein 1

FHR1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q03591
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CFHR1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
FHR-1
EC number
—
Processing
Precursor
Secondary accessions
A8K465, Q3B774, Q9UJ17
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

Disulfide bondGlycoprotein

Disease

Hemolytic uremic syndrome

Domain

RepeatSignalSushi

Cellular component

Secreted

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