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Mephenytoin-d8

CAT: 0804-HY-B1184S2-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1184S2-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mephenytoin-d8 is the deuterium labeled Mephenytoin[1]. Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate[2].
UNSPSC
12352005
Target
Cytochrome P450
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
O=C1N(C([2H])([2H])[2H])C(C(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])(CC)N1)=O
Molecular Formula
C12H6D8N2O2
Molecular Weight
226.30
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Klaassen T, et al. Assessment of urinary mephenytoin metrics to phenotype for CYP2C19 and CYP2B6 activity. Eur J Clin Pharmacol. 2008;64 (4) :387-398.|[3]D R Minck, et al. Comparison of the behavioral teratogenic potential of phenytoin, mephenytoin, ethotoin, and hydantoin in rats. Teratology. 1991 Apr43 (4) :279-93. |[4]J H Maguire, et al. Hypolipidemic activity of antiepileptic 5-phenylhydantoins in mice. Eur J Pharmacol. 1985 Oct 29117 (1) :135-8.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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