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(S) -Mephenytoin

CAT: 0804-HY-B1184A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1184A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(S) -Mephenytoin ((+) -Mephenytoin) is an anticonvulsive agent. (S) -Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19. (S) -Mephenytoin can be used for the analysis of cytochrome P450 metabolism[1][2].
CAS Number
70989-04-7
Product Name Alternative
(+) -Mephenytoin
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-mephenytoin.html
Concentration
10mM
Purity
99.94
Solubility
DMSO : 66.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1N(C)C([C@@](C2=CC=CC=C2)(CC)N1)=O
Molecular Formula
C12H14N2O2
Molecular Weight
218.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Shimada T, et, al. Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction. J Biol Chem. 1986 Jan 15;261 (2) :909-21.|[2]Goldstein JA, et, al. Evidence that CYP2C19 is the major (S) -mephenytoin 4'-hydroxylase in humans. Biochemistry. 1994 Feb 22;33 (7) :1743-52.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP2