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Ambroxol (acefylline)

CAT: 0804-HY-B1039CSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B1039CSize:1 Each
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Description
Ambroxol (NA-872) acefylline, an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol acefylline is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol acefylline induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research[1][2].
CAS Number
96989-76-3
Product Name Alternative
NA-872 (acefylline) ; Acebrophylline
UNSPSC
12352005
Target
Autophagy; Glycosidase
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ambroxol-acefylline.html
Solubility
10 mM in DMSO
Smiles
OC(CN1C2=C(N=C1)N(C(N(C2=O)C)=O)C)=O.O[C@H](CC3)CC[C@@H]3NCC4=C(C(Br)=CC(Br)=C4)N
Molecular Formula
C22H28Br2N6O5
Molecular Weight
616.30
References & Citations
[1]Vojo Deretic, et al. Enhancement of lung levels of antibiotics by ambroxol and bromhexine. Expert Opin Drug Metab Toxicol. 2019 Mar;15 (3) :213-218.|[2]Anna Migdalska-Richards, et al. Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. Ann Neurol. 2016 Nov;80 (5) :766-775.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 4

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