Ambroxol

• Description:

  Ambroxol (NA-872), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research[1][2].

• Product Name Alternative:

  NA-872

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Autophagy; Glycosidase

• Type:

  Reference compound

• Related Pathways:

  Autophagy; Metabolic Enzyme/Protease

• Field of Research:

  Metabolic Disease; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Ambroxol.html

• Concentration:

  10mM

• Purity:

  99.88

• Solubility:

  DMSO : ≥ 200 mg/mL

• Smiles:

  O[C@H]1CC[C@H](NCC2=CC(Br)=CC(Br)=C2N)CC1

• Molecular Formula:

  C13H18Br2N2O

• Molecular Weight:

  378.10

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Vojo Deretic, et al. Enhancement of lung levels of antibiotics by ambroxol and bromhexine. Expert Opin Drug Metab Toxicol. 2019 Mar;15 (3) :213-218.|[2]Anna Migdalska-Richards, et al. Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. Ann Neurol. 2016 Nov;80 (5) :766-775.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  [18683-91-5]