Ambroxol

CAT: 0804-HY-B1039-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B1039-01Size:100 mg
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Description
Ambroxol (NA-872), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research[1][2].
CAS Number
[18683-91-5]
Product Name Alternative
NA-872
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Glycosidase
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Ambroxol.html
Concentration
10mM
Purity
99.88
Solubility
DMSO : ≥ 200 mg/mL
Smiles
O[C@H]1CC[C@H](NCC2=CC(Br)=CC(Br)=C2N)CC1
Molecular Formula
C13H18Br2N2O
Molecular Weight
378.10
Precautions
H302, H315, H319, H335
References & Citations
[1]Vojo Deretic, et al. Enhancement of lung levels of antibiotics by ambroxol and bromhexine. Expert Opin Drug Metab Toxicol. 2019 Mar;15 (3) :213-218.|[2]Anna Migdalska-Richards, et al. Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. Ann Neurol. 2016 Nov;80 (5) :766-775.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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