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Acefylline

CAT: 0804-HY-B1505-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1505-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Acefylline (Theophyllineacetic acid), a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline is a peptidylarginine deiminase (PAD) activator. Acefylline is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline can be used in asthma research[1][2][3].
CAS Number
652-37-9
Product Name Alternative
Theophyllineacetic acid; Theophylline-7-acetic acid
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Adenosine Receptor; Phosphodiesterase (PDE) ; Protein Arginine Deiminase
Type
Natural Products
Related Pathways
Epigenetics; GPCR/G Protein; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Acefylline.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C(O)CN1C=NC(N(C)C(N2C)=O)=C1C2=O
Molecular Formula
C9H10N4O4
Molecular Weight
238.20
Precautions
H302, H315, H319, H335
References & Citations
[1]Ferretti C, et al. Inhibitory effect of theophylline, theophylline-7-acetic acid, ambroxol and ambroxol-theophylline-7-acetate on rat lung cAMP phosphodiesterase isoenzymes. Int J Tissue React. 1992;14 (1) :31-6.|[2]Méchin MC, et, al. Acefylline activates filaggrin deimination by peptidylarginine deiminases in the upper epidermis. J Dermatol Sci. 2016 Feb;81 (2) :101-6.|[3]Tsvetkova B, Tencheva J, Peikov P. Esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether. Acta Pharm. 2006 Jun;56 (2) :251-7. PMID: 16613730.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched

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