Tilmicosin-d3

• Description:

  Tilmicosin-d3 is the deuterium labeled Tilmicosin. Tilmicosin (LY-177370) is an orally active calcium channel antagonist and macrolide antibiotic with antimicrobial activity. Tilmicosin mainly acts on the 50S subunit of bacterial ribosomes, inhibiting protein synthesis. Tilmicosin is effective in the treatment of respiratory diseases in livestock such as cattle, sheep and pigs. In addition, Tilmicosin has immunomodulatory and anti-inflammatory effects[1][2].

• Product Name Alternative:

  LY-177370-d3; EL-870-d3

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H317, H319, H334, H335, H410

• Target:

  Antibiotic; Apoptosis; Bacterial; COX; Isotope-Labeled Compounds; NO Synthase

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Anti-infection; Apoptosis; Immunology/Inflammation; Others

• Field of Research:

  Infection; Inflammation/Immunology

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@@H]([C@@H](CC1=O)O)[C@H]([C@H](C[C@H](C(/C=C/C(C)=C/[C@H](CO[C@H](O[C@H](C)[C@@H](O)[C@H]2OC)[C@@H]2OC)[C@@H](CC)O1)=O)C)CCN(C[C@H](C)C3)C[C@H]3C)O[C@@](O[C@H](C)[C@@H](O)[C@@H]4N(C)C([2H])([2H])[2H])([H])[C@@H]4O

• Molecular Formula:

  C46H77D3N2O13

• Molecular Weight:

  872.15

• Precautions:

  H315, H317, H319, H334, H335, H410

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Micotil 300 New Animal Drug Application

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [2714486-61-8]