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Tilmicosin (phosphate) (Standard)

CAT: 0804-HY-B0905AR-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0905AR-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tilmicosin (phosphate) (Standard) is the analytical standard of Tilmicosin (phosphate) . This product is intended for research and analytical applications. Tilmicosin (LY-177370) phosphate is an orally active calcium channel antagonist and macrolide antibiotic with antimicrobial activity. Tilmicosin phosphate mainly acts on the 50S subunit of bacterial ribosomes, inhibiting protein synthesis. Tilmicosin phosphate is effective in the treatment of respiratory diseases in livestock such as cattle, sheep and pigs. In addition, Tilmicosin phosphate has immunomodulatory and anti-inflammatory effects[1][2][3][4][5][6].
CAS Number
137330-13-3
Product Name Alternative
LY-177370 phosphate (Standard) ; EL-870 phosphate (Standard)
UNSPSC
12352005
Target
Antibiotic; Apoptosis; Bacterial; COX; NO Synthase; Reference Standards
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; Others
Field of Research
Infection; Inflammation/Immunology
Smiles
C[C@@H]([C@@H](CC1=O)O)[C@H]([C@H](C[C@H](C(/C=C/C(C)=C/[C@H](CO[C@H](O[C@H](C)[C@@H](O)[C@H]2OC)[C@@H]2OC)[C@@H](CC)O1)=O)C)CCN(C[C@H](C)C3)C[C@H]3C)O[C@@](O[C@H](C)[C@@H](O)[C@@H]4N(C)C)([H])[C@@H]4O.O=P(O)(O)O
Molecular Formula
C46H83N2O17P
Molecular Weight
967.13
References & Citations
[1]Ziv G, et al. Tilmicosin antibacterial activity and pharmacokinetics in cows. J Vet Pharmacol Ther. 1995 Oct;18 (5) :340-5. |[2]Buret AG. Immuno-modulation and anti-inflammatory benefits of antibiotics: the example of tilmicosin. Can J Vet Res. 2010 Jan;74 (1) :1-10.|[3]Cao XY, et al. Tilmicosin and tylosin have anti-inflammatory properties via modulation of COX-2 and iNOS gene expression and production of cytokines in LPS-induced macrophages and monocytes. Int J Antimicrob Agents. 2006 May;27 (5) :431-8.|[4]Ibrahim AE, et al. Modulating Effects of Spirulina platensis against Tilmicosin-Induced Cardiotoxicity in Mice. Cell J. 2015 Spring;17 (1) :137-44.|[5]Zhang N, et al. Pharmacokinetic and Pharmacodynamic integration of tilmicosin against Mycoplasma gallisepticum in the target infection site in chickens. Front Vet Sci. 2022 Sep 29;9:952599. |[6]Veenhuizen MF, et al. Analysis of reports of human exposure to Micotil 300 (tilmicosin injection) . J Am Vet Med Assoc. 2006 Dec 1;229 (11) :1737-42.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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