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Tilmicosin

CAT: 0804-HY-B0905-01Size: 100 mgDry Ice: NoHazardous: No
CAT#: HY-B0905-01Size: 100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tilmicosin (LY-177370) is an orally active calcium channel antagonist and macrolide antibiotic with antimicrobial activity. Tilmicosin mainly acts on the 50S subunit of bacterial ribosomes, inhibiting protein synthesis. Tilmicosin is effective in the treatment of respiratory diseases in livestock such as cattle, sheep and pigs. In addition, Tilmicosin has immunomodulatory and anti-inflammatory effects[1][2][3][4][5][6].
CAS Number
[108050-54-0]
Product Name Alternative
LY-177370; EL-870
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Apoptosis; Bacterial; Calcium Channel
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Tilmicosin.html
Purity
98.0
Solubility
1M HCl : 100 mg/mL (ultrasonic; adjust pH to 1 with HCl) |DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@H]([C@@H](CC1=O)O)[C@H]([C@H](C[C@H](C(/C=C/C(C)=C/[C@H](CO[C@H](O[C@H](C)[C@@H](O)[C@H]2OC)[C@@H]2OC)[C@@H](CC)O1)=O)C)CCN(C[C@H](C)C3)C[C@H]3C)O[C@@](O[C@H](C)[C@@H](O)[C@@H]4N(C)C)([H])[C@@H]4O
Molecular Formula
C46H80N2O13
Molecular Weight
869.13
Precautions
H302, H315, H319, H335
References & Citations
[1]Ziv G, et al. Tilmicosin antibacterial activity and pharmacokinetics in cows. J Vet Pharmacol Ther. 1995 Oct;18 (5) :340-5.|[2]Buret AG. Immuno-modulation and anti-inflammatory benefits of antibiotics: the example of tilmicosin. Can J Vet Res. 2010 Jan;74 (1) :1-10.|[3]Cao XY, et al. Tilmicosin and tylosin have anti-inflammatory properties via modulation of COX-2 and iNOS gene expression and production of cytokines in LPS-induced macrophages and monocytes. Int J Antimicrob Agents. 2006 May;27 (5) :431-8. |[4]Ibrahim AE, et al. Modulating Effects of Spirulina platensis against Tilmicosin-Induced Cardiotoxicity in Mice. Cell J. 2015 Spring;17 (1) :137-44.|[5]Zhang N, et al. Pharmacokinetic and Pharmacodynamic integration of tilmicosin against Mycoplasma gallisepticum in the target infection site in chickens. Front Vet Sci. 2022 Sep 29;9:952599.|[6]Veenhuizen MF, et al. Analysis of reports of human exposure to Micotil 300 (tilmicosin injection) . J Am Vet Med Assoc. 2006 Dec 1;229 (11) :1737-42.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-2

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