Urapidil-d4

• Description:

  Urapidil-d4 is the deuterium labeled Urapidil[1]. Urapidil is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist[2].

• UNSPSC:

  12352005

• Target:

  5-HT Receptor; Adrenergic Receptor; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling; Others

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Endocrinology

• Solubility:

  DMSO : 25 mg/mL (ultrasonic; warming)

• Smiles:

  COC1=C (N2CC ([2H]) ([2H]) N (C ([2H]) ([2H]) C2) CCCNC (N (C (N3C) =O) C) =CC3=O) C=CC=C1

• Molecular Formula:

  C20H25D4N5O3

• Molecular Weight:

  391.50

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Bopp C, et al. The effect of urapidil, an alpha-1 adrenoceptor antagonist and a 5-HT1A agonist, on the vascular tone of the porcine coronary and pulmonary arteries, the rat aorta and the human pulmonary artery. Eur J Pharmacol. 2016 May 15;779:53-8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• Isoform:

  5-HT1 Receptor; mLAG-3

• CAS Number:

  1795122-12-1