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Phenoxybenzamine-d5

CAT: 0804-HY-B0431SSize: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0431SSize:1 mg
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Description
Phenoxybenzamine-d5 is the deuterium labeled Phenoxybenzamine[1]. Phenoxybenzamine is a nonselective, irreversible, orally active α-adrenoceptor antagonist that is commonly used for the research of hypertension, specifically caused by pheochromocytoma. Phenoxybenzamine also shows antitumor activity[2][3].
CAS Number
[1309283-11-1]
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
CC(COC1=CC=CC=C1)N(CCCl)CC2=C([2H])C([2H])=C([2H])C([2H])=C2[2H]
Molecular Formula
C18H17D5ClNO
Molecular Weight
308.86
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Habbe N, et al. Urapidil in the preoperative treatment of pheochromocytomas: a safe and cost-effective method. World J Surg. 2013 May;37 (5) :1141-6.|[3]Lin XB, et al. Anti-tumor activity of phenoxybenzamine hydrochloride on malignant glioma cells. Tumour Biol. 2016 Mar37 (3) :2901-8.|[4]Rau TF, et al. Phenoxybenzamine is neuroprotective in a rat model of severe traumatic brain injury. Int J Mol Sci. 2014 Jan 2015 (1) :1402-17.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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