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Phenoxybenzamine

CAT: 0804-HY-B0431Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-B0431Size:1 Each
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Description
Phenoxybenzamine is a nonselective, irreversible, orally active α-adrenoceptor antagonist that is commonly used for the research of hypertension, specifically caused by pheochromocytoma. Phenoxybenzamine also shows antitumor activity[1][2].
CAS Number
[59-96-1]
UNSPSC
12352005
Hazard Statement
H302-H351
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Endocrinology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/phenoxybenzamine.html
Solubility
10 mM in DMSO
Smiles
CC(N(CCCl)CC1=CC=CC=C1)COC2=CC=CC=C2
Molecular Formula
C18H22ClNO
Molecular Weight
303.83
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Habbe N, et al. Urapidil in the preoperative treatment of pheochromocytomas: a safe and cost-effective method. World J Surg. 2013 May;37 (5) :1141-6.|[2]Lin XB, et al. Anti-tumor activity of phenoxybenzamine hydrochloride on malignant glioma cells. Tumour Biol. 2016 Mar;37 (3) :2901-8.|[3]Rau TF, et al. Phenoxybenzamine is neuroprotective in a rat model of severe traumatic brain injury. Int J Mol Sci. 2014 Jan 20;15 (1) :1402-17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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