Phenoxybenzamine

• Description :

  Phenoxybenzamine is a nonselective, irreversible, orally active α-adrenoceptor antagonist that is commonly used for the research of hypertension, specifically caused by pheochromocytoma. Phenoxybenzamine also shows antitumor activity[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H351

• Target :

  Adrenergic Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Cancer; Endocrinology; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/phenoxybenzamine.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(N(CCCl)CC1=CC=CC=C1)COC2=CC=CC=C2

• Molecular Formula :

  C18H22ClNO

• Molecular Weight :

  303.83

• Precautions :

  P264-P270-P330-P405-P501

• References & Citations :

  [1]Habbe N, et al. Urapidil in the preoperative treatment of pheochromocytomas: a safe and cost-effective method. World J Surg. 2013 May;37 (5) :1141-6.|[2]Lin XB, et al. Anti-tumor activity of phenoxybenzamine hydrochloride on malignant glioma cells. Tumour Biol. 2016 Mar;37 (3) :2901-8.|[3]Rau TF, et al. Phenoxybenzamine is neuroprotective in a rat model of severe traumatic brain injury. Int J Mol Sci. 2014 Jan 20;15 (1) :1402-17.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [59-96-1]