Dipyridamole-d16

Dipyridamole-d16

• UNSPSC Description: Dipyridamole-d16 is the deuterium labeled Dipyridamole. Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.
• Target Antigen: Phosphodiesterase (PDE)
• Type: Isotope-Labeled Compounds
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Cardiovascular Disease
• Solubility: 10 mM in DMSO
• Smiles: OC([2H])(C([2H])(N(C1=NC2=C(C(N3CCCCC3)=N1)N=C(N=C2N4CCCCC4)N(C([2H])(C([2H])(O)[2H])[2H])C([2H])(C([2H])(O)[2H])[2H])C([2H])(C([2H])(O)[2H])[2H])[2H])[2H]
• Molecular Weight: 520.72
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Klabunde, R.E., Dipyridamole inhibition of adenosine metabolism in human blood. Eur J Pharmacol, 1983. 93(1-2): p. 21-6.|[3]Best, L.C., et al., Mode of action of dipyridamole on human platelets. Thromb Res, 1979. 16(3-4): p. 367-79.|[4]Aktas, B., et al., Dipyridamole enhances NO/cGMP-mediated vasodilator-stimulated phosphoprotein phosphorylation and signaling in human platelets: in vitro and in vivo/ex vivo studies. Stroke, 2003. 34(3): p. 764-9.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported