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Acetylcholine-d9 (chloride)

CAT: 0804-HY-B0282S1-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0282S1-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Acetylcholine-d9 (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs) [1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].
CAS Number
344298-95-9
Product Name Alternative
ACh-d9 (chloride)
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
Calcium Channel; Endogenous Metabolite; nAChR
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Neurological Disease; Cancer
Purity
99.0
Solubility
10 mM in DMSO|DMSO : 62.5mg/mL (ultrasonic) |H2O : 100mg/mL (ultrasonic)
Smiles
CC(OCC[N+](C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O.[Cl-]
Molecular Formula
C7H7D9ClNO2
Molecular Weight
190.72
Precautions
H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Prashant Tiwari, et al. Basic and modern concepts on cholinergic receptor: A review. Asian Pac J Trop Dis. 2013 Oct;3 (5) : 413-420.|[3]A Young, et al. Diarrhoea of famine and malnutrition--investigations using a rat model. 2--Ileal hypersecretion induced by starvation. Gut. 1990 Feb;31 (2) :162-9.|[4]Xia Lei, et al. Effects of acetylcholine chloride on intracellular calcium concentration of cultured sweat gland epithelial cells. Arch Dermatol Res. 2008 Aug;300 (7) :335-41.|[5]P F Zabrodskii, et al. Effect of acetylcholine on mortality of mice from sepsis and proinflammatory cytokine production. Bull Exp Biol Med. 2011 Jan;150 (3) :340-2.|[6]Zhaolin Chen, et al. Inhibition of p53 Mutant Peptide Aggregation In Vitro by Cationic Osmolyte Acetylcholine Chloride. Protein Pept Lett. 2017;24 (4) :353-357.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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