Acetylcholine (chloride)

• UNSPSC Description:

  Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].

• Target Antigen:

  Calcium Channel; Endogenous Metabolite; nAChR

• Type:

  Natural Products

• Related Pathways:

  Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Neurological Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Acetylcholine-chloride.html

• Purity:

  99.40

• Solubility:

  DMSO : 62.5 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(OCC[N+](C)(C)C)C.[Cl-]

• Molecular Weight:

  181.66

• References & Citations:

  [1]Prashant Tiwari, et al. Basic and modern concepts on cholinergic receptor: A review. Asian Pac J Trop Dis. 2013 Oct;3(5): 413-420.|[2]A Young, et al. Diarrhoea of famine and malnutrition--investigations using a rat model. 2--Ileal hypersecretion induced by starvation. Gut. 1990 Feb;31(2):162-9.|[3]Xia Lei, et al. Effects of acetylcholine chloride on intracellular calcium concentration of cultured sweat gland epithelial cells. Arch Dermatol Res. 2008 Aug;300(7):335-41.|[4]P F Zabrodskii, et al. Effect of acetylcholine on mortality of mice from sepsis and proinflammatory cytokine production. Bull Exp Biol Med. 2011 Jan;150(3):340-2.|[5]Zhaolin Chen, et al. Inhibition of p53 Mutant Peptide Aggregation In Vitro by Cationic Osmolyte Acetylcholine Chloride. Protein Pept Lett. 2017;24(4):353-357.Biochim Biophys Acta Mol Basis Dis. 2024 Aug 30:167488.|Biomed Pharmacother. 2024 Jul 12:177:117105.|bioRxiv. 2023 Oct 13.|BMC Pulm Med. 2021 Jun 5;21(1):189.|Cells. 2024 Oct 14;13(20):1697.|Front Cardiovasc Med. 2021 Jun 16;8:679240.|J Ethnopharmacol. 2024 Aug 22:118707.|J Hazard Mater. 2023 Dec 14, 133248.|J Hazard Mater. 2024 Sep 5:479:135690.|Mol Metab. 2023 Sep 26, 101811.|Proc Natl Acad Sci U S A. 2024 June 26.|Redox Biol. 2023 Dec 18:69:103004.|Int J Mol Sci. 2023 Apr 16, 24(8), 7356.|Nat Commun. 2023 Sep 21;14(1):5891.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  Launched

• CAS Number:

  60-31-1