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Amifostine (trihydrate)

CAT: 0804-HY-B0639A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0639A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Amifostine trihydrate (WR2721 trihydrate) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine trihydrate selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine trihydrate is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine trihydrate protects cells from damage by scavenging oxygen-derived free radicals. Amifostine trihydrate reduces renal toxicity and has antiangiogenic action[1][2][3][4].
CAS Number
112901-68-5
Product Name Alternative
WR2721 (trihydrate)
UNSPSC
12352211
Hazard Statement
H302
Target
HIF/HIF Prolyl-Hydroxylase; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/amifostine-trihydrate.html
Purity
99.95
Solubility
H2O : 70 mg/mL (ultrasonic)
Smiles
OP(SCCNCCCN)(O)=O.[H]O[H].[H]O[H].[H]O[H]
Molecular Formula
C5H21N2O6PS
Molecular Weight
268.27
Precautions
H302
References & Citations
[1]D Maurici, et al. Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay. Oncogene. 2001 Jun 14;20 (27) :3533-40.|[2]Efstathia Giannopoulou, et al. Amifostine inhibits angiogenesis in vivo. J Pharmacol Exp Ther. 2003 Feb;304 (2) :729-37.|[3]Michael I Koukourakis, et al. Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha. Cancer Chemother Pharmacol. 2004 Jan;53 (1) :8-14.|[4]John R Kouvaris, et al. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist. 2007 Jun;12 (6) :738-47.|[5]Shao-Ze Wu, et al. Amifostine Pretreatment Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Apoptosis and Oxidative Stress. Oxid Med Cell Longev. 2017;2017:4130824.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Launched

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