Rizatriptan-d6 (benzoate)

CAT: 0804-HY-B0206SSize: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0206SSize:1 mg
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Description
Rizatriptan-d6 (benzoate) is the deuterium labeled Rizatriptan benzoate. Rizatriptan benzoate is the agonist for 5-HT1B and 5-HT1D. Rizatriptan benzoate has a peripheral vasoconstrictive effect, penetrates the intact blood-brain barrier, and inhibits pain neurotransmission in the central nervous system[2].
CAS Number
[1216984-85-8]
UNSPSC
12352005
Target
5-HT Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
C(O)(=O)C1=CC=CC=C1.C(CN(C([2H])([2H])[2H])C([2H])([2H])[2H])C=1C=2C(NC1)=CC=C(CN3C=NC=N3)C2
Molecular Formula
C22H19D6N5O2
Molecular Weight
397.50
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Sciberras DG, et al. Initial human experience with MK-462 (rizatriptan) : a novel 5-HT1D agonist. Br J Clin Pharmacol. 1997 Jan;43 (1) :49-54.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor

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