Rizatriptan (benzoate)

• Description :

  Rizatriptan benzoate is the agonist for 5-HT1B and 5-HT1D. Rizatriptan benzoate has a peripheral vasoconstrictive effect, penetrates the intact blood-brain barrier, and inhibits pain neurotransmission in the central nervous system[2].

• Product Name Alternative :

  MK 462

• UNSPSC :

  12352005

• Hazard Statement :

  H360

• Target :

  5-HT Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/rizatriptan-benzoate.html

• Purity :

  99.93

• Solubility :

  DMSO : 50 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

• Smiles :

  CN(C)CCC1=CNC2=C1C=C(CN3N=CN=C3)C=C2.O=C(O)C4=CC=CC=C4

• Molecular Formula :

  C22H25N5O2

• Molecular Weight :

  391.47

• Precautions :

  H360

• References & Citations :

  [1]Sciberras DG, et al. Initial human experience with MK-462 (rizatriptan) : a novel 5-HT1D agonist. Br J Clin Pharmacol. 1997 Jan;43 (1) :49-54.|[2]Cumberbatch MJ, et al. Rizatriptan has central antinociceptive effects against durally evoked responses. Eur J Pharmacol. 1997 Jun 5;328 (1) :37-40.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  5-HT1 Receptor; mLAG-3

• CAS Number :

  [145202-66-0]